ABT-239

Also known as: (R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE, (R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)- ethyl)benzofuran-5-yl)benzonitril, (R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)Ethyl)benzofuran-5-yl)benzonitrile, (R)-4-[2-[2-(2-Methylpyrrolidinyl)ethyl]benzofuran-5-yl]benzonitrile, 4-(2-{2-[(2R)-2-Methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, ABT 239, ABT-239 (ABT239, ABT-239, 10 mM in DMSO, Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-

ABT-239 (CAS 460746-46-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H22N2O and a molecular weight of 330.42300 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 460746-46-7
Jingsj CID: J-1970882-8
Molecular Formula: C₂₂H₂₂N₂O
Molecular Weight: 330.42300 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	330.17300
PSA	40.17000
LogP	4.93618
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Bhowmik M, et al. Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice. Brain Res. 2014 Sep 18;1581:129-40. [2]. Provensi G, et al. Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse. Neuropharmacolo [3]. Kruk M, e tal. Effects of the histamine H2 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice. Pharmacol Rep. 2012;64(6):1316-25. [4]. Munari L, et al. Selective brain region activation by histamine H2 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression. Neuropharmacology. 2013 Jul;70:131-40.

Additional Information

[1]. Bhowmik M, et al. Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice. Brain Res. 2014 Sep 18;1581:129-40. [2]. Provensi G, et al. Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse. Neuropharmacolo [3]. Kruk M, e tal. Effects of the histamine H2 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice. Pharmacol Rep. 2012;64(6):1316-25. [4]. Munari L, et al. Selective brain region activation by histamine H2 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression. Neuropharmacology. 2013 Jul;70:131-40.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of ABT-239?

The CAS number of ABT-239 is 460746-46-7.

What are the molecular formula and molecular weight of ABT-239?

ABT-239 has molecular formula C22H22N2O and molecular weight 330.42300 g/mol.

What are the upstream and downstream products of ABT-239?

For ABT-239, Upstream Products: 4'-hydroxy-3'-iodo-[1,1'-biphenyl]-4-carbonitrile, (2R)-1-but-3-yn-1-yl-2-methylpyrrolidine, 4'-Hydroxy-4-biphenylcarbonitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "ABT-239 (CAS 460746-46-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1970882-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.