3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid

Also known as: GSK-J1, N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid, Histone Lysine Demethylase Inhibitor VII, GSK-J1 (lithium salt)

3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid (CAS 1373422-53-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C22H23N5O2 and a molecular weight of 389.450 g/mol. Key properties include a boiling point of 608.9±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 322.0±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1373422-53-7
Jingsj CID: J-1970687-7
Molecular Formula: C₂₂H₂₃N₅O₂
Molecular Weight: 389.450 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	608.9±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	322.0±31.5 °C
Exact Mass	389.185181
PSA	91.24000
LogP	2.75
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.653
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: 60 nM (KDM6B)[2]
Additional Information	[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [2]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. [3]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46.

Target

IC50: 60 nM (KDM6B)[2]

Additional Information

[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [2]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. [3]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46.

Frequently Asked Questions

What is the CAS number of 3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid?

The CAS number of 3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid is 1373422-53-7.

What are the molecular formula and molecular weight of 3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid?

3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid has molecular formula C22H23N5O2 and molecular weight 389.450 g/mol.

What are the upstream and downstream products of 3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid?

For 3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid, Upstream Products: 2,3,4,5-Tetrahydro-1H-3-benzazepine hydrochloride, 4,6-Dichloro-2-(pyridin-2-yl)pyrimidine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3-[[6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-2-pyridin-2-ylpyrimidin-4-yl]amino]propanoic acid (CAS 1373422-53-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1970687-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.