Rhapontigenin

Also known as: (E)-5-(3-Hydroxy-4-methoxystyryl)benzene-1,3-diol, 1,3-Benzenediol, 5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-, 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene, 5-[(E)-2-(3-Hydroxy-4-methoxyphenyl)vinyl]-1,3-benzenediol, trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene, Protigenin

Rhapontigenin (CAS 500-65-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H14O4 and a molecular weight of 258.269 g/mol. Key properties include a melting point of 186-187ºC, a boiling point of 503.6±38.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 258.4±26.8 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 500-65-2
Jingsj CID: J-1970338-9
Molecular Formula: C₁₅H₁₄O₄
Molecular Weight: 258.269 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	186-187ºC
Boiling Point	503.6±38.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	258.4±26.8 °C
Exact Mass	258.089203
PSA	69.92000
LogP	2.82
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.722

Activity & Biological Data

Target	CYP1A1:400 nM (IC50)
Additional Information	[1]. Roupe KA, et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.J Pharm Pharm Sci. 2005 Aug 22;8(3):374-86. [2]. Yeh YH, et al. Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation.Oncol Rep. 2016 May;35(5):2887-95. [3]. Park EK, et al. Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria.Arch Pharm Res. 2002 Aug;25(4):528-33.

Target

CYP1A1:400 nM (IC50)

Additional Information

[1]. Roupe KA, et al. Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.J Pharm Pharm Sci. 2005 Aug 22;8(3):374-86. [2]. Yeh YH, et al. Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation.Oncol Rep. 2016 May;35(5):2887-95. [3]. Park EK, et al. Antithrombotic and antiallergic activities of rhaponticin from Rhei Rhizoma are activated by human intestinal bacteria.Arch Pharm Res. 2002 Aug;25(4):528-33.

Frequently Asked Questions

What is the CAS number of Rhapontigenin?

The CAS number of Rhapontigenin is 500-65-2.

What are the molecular formula and molecular weight of Rhapontigenin?

Rhapontigenin has molecular formula C15H14O4 and molecular weight 258.269 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rhapontigenin (CAS 500-65-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1970338-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.