Nonapeptide-1

Also known as: Nonapeptide-1, Melanostatine, Melanostatine-5, H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide, Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, Melanostatin-1, Nonapeptide 1

Nonapeptide-1 (CAS 158563-45-2) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C61H87N15O9S and a molecular weight of 1206.504 g/mol. Key property: a density of 1.4±0.1 g/cm3. It is listed by 1 supplier; request a quote for pricing. Record last updated Aug 21, 2026.

CAS No.: 158563-45-2
Jingsj CID: J-1970323-5
Molecular Formula: C₆₁H₈₇N₁₅O₉S
Molecular Weight: 1206.504 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	1205.653198
PSA	413.34000
LogP	3.90
Refractive Index	1.672

Activity & Biological Data

Target	MC1R:40 nM (Ki) MC3R:0.47 μM (Ki) MC4R:1.34 μM (Ki) MC5R:2.4 μM (Ki)
Additional Information	[1]. Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54. [2]. Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997). [3]. Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335.

Target

MC1R:40 nM (Ki) MC3R:0.47 μM (Ki) MC4R:1.34 μM (Ki) MC5R:2.4 μM (Ki)

Additional Information

[1]. Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54. [2]. Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997). [3]. Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335.

Frequently Asked Questions

What is the CAS number of Nonapeptide-1?

The CAS number of Nonapeptide-1 is 158563-45-2.

What are the molecular formula and molecular weight of Nonapeptide-1?

Nonapeptide-1 has molecular formula C61H87N15O9S and molecular weight 1206.504 g/mol.

Which suppliers offer Nonapeptide-1?

1 supplier(s) listed; request a quote for pricing.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Nonapeptide-1 (CAS 158563-45-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1970323-5 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.