VE-821

Also known as: 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-, 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide, 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide, 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide VE-821, 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide, 3-amino-6-(4-methylsulfonylphenyl)-N-phenylpyrazine-2-carboxamide, CS-0238, CS-634, VE 821, VE-821 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide, VE821

VE-821 (CAS 1232410-49-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C18H16N4O3S and a molecular weight of 368.410 g/mol. Key properties include a boiling point of 568.4±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 297.6±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1232410-49-9
Jingsj CID: J-1970113-4
Molecular Formula: C₁₈H₁₆N₄O₃S
Molecular Weight: 368.410 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	568.4±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	297.6±30.1 °C
Exact Mass	368.094299
PSA	126.91000
LogP	2.93
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.658
Storage Conditions	-20°C

Activity & Biological Data

Target	ATR:13 nM (Ki) ATM:16 μM (Ki) DNA-PK:2.2 μM (Ki) PI3Kγ:3.9 μM (Ki)
Additional Information	[1]. Reaper PM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. [2]. Charrier JD, et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. [3]. Prevo R, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. [4]. Muralidharan SV, et al. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Sep 8;35(36):4689-97.

Target

ATR:13 nM (Ki) ATM:16 μM (Ki) DNA-PK:2.2 μM (Ki) PI3Kγ:3.9 μM (Ki)

Additional Information

[1]. Reaper PM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. [2]. Charrier JD, et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. [3]. Prevo R, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. [4]. Muralidharan SV, et al. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Sep 8;35(36):4689-97.

Frequently Asked Questions

What is the CAS number of VE-821?

The CAS number of VE-821 is 1232410-49-9.

What are the molecular formula and molecular weight of VE-821?

VE-821 has molecular formula C18H16N4O3S and molecular weight 368.410 g/mol.

What are the upstream and downstream products of VE-821?

For VE-821, Upstream Products: Methyl 3-amino-2-pyrazinecarboxylate, Methyl 3-amino-6-bromopyrazine-2-carboxylate, 3-Amino-6-bromopyrazine-2-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "VE-821 (CAS 1232410-49-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1970113-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.