naphtho[1,2-d]thiazol-2-amine

Also known as: 2-amino-beta-naphthothiazole, SKA-31, 2-aminonaphtho[1,2-d]thiazole, 2-aminonaphtho-1,2-thiazole, benzo[e][1,3]benzothiazol-2-amine, naphtho[1,2-d]thiazol-2-ylamine, NSC 6278, AKOS BBS-00006561, IFLAB-BB F1386-0401, LABOTEST-BB LT00154570

naphtho[1,2-d]thiazol-2-amine (CAS 40172-65-4) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C11H8N2S and a molecular weight of 200.26 g/mol. Key properties include a melting point of 184-188ºC, a boiling point of 417.1ºC at 760 mmHg, a density of 1.403g/cm3 and a flash point of 206.1ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 40172-65-4
Jingsj CID: J-1969548-8
Molecular Formula: C₁₁H₈N₂S
Molecular Weight: 200.26 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	184-188ºC
Boiling Point	417.1ºC at 760 mmHg
Density	1.403g/cm3
Flash Point	206.1ºC
Exact Mass	200.04100
PSA	67.15000
LogP	3.61290
Refractive Index	1.83
Storage Conditions	Store at +4°C

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H319 — Causes serious eye irritation

Activity & Biological Data

Target	EC50: 2.9 μM (KCa2.1), 1.9 μM (KCa2.2), 2.9 μM (KCa2.3), 260 nM (KCa3.1)[1]
Additional Information	[1]. Sankaranarayanan A, et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95. [2]. Serena Pillozzi, et al. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 Jan; 118(2): 200–212.

Target

EC50: 2.9 μM (KCa2.1), 1.9 μM (KCa2.2), 2.9 μM (KCa2.3), 260 nM (KCa3.1)[1]

Additional Information

[1]. Sankaranarayanan A, et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95. [2]. Serena Pillozzi, et al. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 Jan; 118(2): 200–212.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of naphtho[1,2-d]thiazol-2-amine?

The CAS number of naphtho[1,2-d]thiazol-2-amine is 40172-65-4.

What are the molecular formula and molecular weight of naphtho[1,2-d]thiazol-2-amine?

naphtho[1,2-d]thiazol-2-amine has molecular formula C11H8N2S and molecular weight 200.26 g/mol.

Is naphtho[1,2-d]thiazol-2-amine hazardous?

naphtho[1,2-d]thiazol-2-amine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H319 — Causes serious eye irritation.

What are the upstream and downstream products of naphtho[1,2-d]thiazol-2-amine?

For naphtho[1,2-d]thiazol-2-amine, Upstream Products: 1-Tetralone, Naphtox, Potassium thiocyanate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "naphtho[1,2-d]thiazol-2-amine (CAS 40172-65-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1969548-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.