![Molecular structure of 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid (CAS 307510-92-5)](/images/chem_structures_svg/328/307510-92-5.svg)
4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
Also known as: CFTR(inh)-172, CFTRinh-172, CFTR inhibitor 172, 4-[(Z)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid, Benzoic acid, 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-, Benzoic acid, 4-[(Z)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid (CAS 307510-92-5) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C18H10F3NO3S2 and a molecular weight of 409.402 g/mol. Key properties include a boiling point of 555.7±60.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 289.9±32.9 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H317 — May cause an allergic skin reaction and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 307510-92-5
- Jingsj CID
- J-1969515-9
- Molecular Formula
- C18H10F3NO3S2
- Molecular Weight
- 409.402 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 555.7±60.0 °C at 760 mmHg |
|---|---|
| Density | 1.6±0.1 g/cm3 |
| Flash Point | 289.9±32.9 °C |
| Exact Mass | 409.005432 |
| PSA | 115.00000 |
| LogP | 4.51 |
| Appearance | yellow |
| Vapor Pressure | 0.0±1.6 mmHg at 25°C |
| Refractive Index | 1.698 |
| Storage Conditions | Store at +4°C |
| Additional Property | DMSO: ≥10mg/mL |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H317 — May cause an allergic skin reaction
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
- H410 — Very toxic to aquatic life with long lasting effects
Activity & Biological Data
| Target | Ki: 300 nM (CFTR)[1] |
|---|---|
| Additional Information | [1]. Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8. [2]. Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6. |
Frequently Asked Questions
What is the CAS number of 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid?
The CAS number of 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid is 307510-92-5.
What are the molecular formula and molecular weight of 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid?
4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid has molecular formula C18H10F3NO3S2 and molecular weight 409.402 g/mol.
Is 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid hazardous?
4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H317 — May cause an allergic skin reaction; H319 — Causes serious eye irritation.
What are the upstream and downstream products of 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid?
For 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid, Upstream Products: 2-Thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one, 4-Formylbenzoic acid, 3-(Trifluoromethyl)aniline.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid (CAS 307510-92-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1969515-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.