Olesoxime

Also known as: TRO 19622, TRO-19622, TRO19622, TRO19266, NSC 21311, Cholest-4-en-3-one oxime, (3E)-cholest-4-en-3-one oxime, 3-oxyimino-cholest-4-ene

Olesoxime (CAS 22033-87-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C27H45NO and a molecular weight of 399.65200 g/mol. Key properties include a melting point of 145-148ºC, a boiling point of 510ºC at 760mmHg, a density of 1.1 and a flash point of 341ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 22033-87-0
Jingsj CID: J-1969480-5
Molecular Formula: C₂₇H₄₅NO
Molecular Weight: 399.65200 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	145-148ºC
Boiling Point	510ºC at 760mmHg
Density	1.1
Flash Point	341ºC
Exact Mass	399.35000
PSA	32.59000
LogP	7.85800
Vapor Pressure	1.56E-12mmHg at 25°C
Refractive Index	1.583
Storage Conditions	−20°C

Activity & Biological Data

Target	Mitochondrial[1]
Additional Information	[1]. Martin LJ, et al. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Aug;13(8):568-80. [2]. Bordet T, et al. Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound. Pharmaceuticals (Basel). 2010 Jan 28;3(2):345-368 [3]. Bordet T, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20. [4]. Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147(1-3):202-9

Target

Mitochondrial[1]

Additional Information

[1]. Martin LJ, et al. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Aug;13(8):568-80. [2]. Bordet T, et al. Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound. Pharmaceuticals (Basel). 2010 Jan 28;3(2):345-368 [3]. Bordet T, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322(2):709-20. [4]. Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147(1-3):202-9

Frequently Asked Questions

What is the CAS number of Olesoxime?

The CAS number of Olesoxime is 22033-87-0.

What are the molecular formula and molecular weight of Olesoxime?

Olesoxime has molecular formula C27H45NO and molecular weight 399.65200 g/mol.

What are the upstream and downstream products of Olesoxime?

For Olesoxime, Upstream Products: Cholest-4-en-3-one; Downstream Products: Cholest-4-en-3-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Olesoxime (CAS 22033-87-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1969480-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.