Barasertib (AZD1152-HQPA)

Also known as: 1H-Pyrazole-5-acetamide, 3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-, 2-{3-[(7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide, 2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide, 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide, AZD-1152-HQPA, AZD1152 HPQA, AZD1152-HQPA, Barasertib, INH 34

Barasertib (AZD1152-HQPA) (CAS 722544-51-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H30FN7O3 and a molecular weight of 507.560 g/mol. Key properties include a boiling point of 796.7±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 435.6±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 722544-51-6
Jingsj CID: J-1963217-8
Molecular Formula: C₂₆H₃₀FN₇O₃
Molecular Weight: 507.560 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	796.7±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	435.6±32.9 °C
Exact Mass	507.239410
PSA	128.29000
LogP	2.82
Appearance	white to beige
Vapor Pressure	0.0±2.9 mmHg at 25°C
Refractive Index	1.677
Storage Conditions	2-8°C
Additional Property	DMSO: >15mg/mL

Activity & Biological Data

Target	Aurora B:0.37 nM (IC50)
Additional Information	[1]. Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8. [2]. Yang, Jing., et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15;110(6):2034-40. [3]. Zekri A, et al. AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy. Tumour Biol. 2015 Feb;36(2):623-32.

Target

Aurora B:0.37 nM (IC50)

Additional Information

[1]. Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8. [2]. Yang, Jing., et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15;110(6):2034-40. [3]. Zekri A, et al. AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy. Tumour Biol. 2015 Feb;36(2):623-32.

Frequently Asked Questions

What is the CAS number of Barasertib (AZD1152-HQPA)?

The CAS number of Barasertib (AZD1152-HQPA) is 722544-51-6.

What are the molecular formula and molecular weight of Barasertib (AZD1152-HQPA)?

Barasertib (AZD1152-HQPA) has molecular formula C26H30FN7O3 and molecular weight 507.560 g/mol.

What are the upstream and downstream products of Barasertib (AZD1152-HQPA)?

For Barasertib (AZD1152-HQPA), Upstream Products: 2-(Ethylamino)ethanol, 5-Amino-1H-pyrazole-3-acetic acid, 7-(3-Hydroxypropoxy)quinazolin-4(3H)-one; Downstream Products: Barasertib.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Barasertib (AZD1152-HQPA) (CAS 722544-51-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963217-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.