Resatorvid

Also known as: TAK-242, TAK 242, CLI-095, Ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate, Ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]-1-cyclohexene-1-carboxylate, (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester, 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester, (6R)-, UNII-H2MZ648C31

Resatorvid (CAS 243984-11-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H17ClFNO4S and a molecular weight of 361.816 g/mol. Key properties include a melting point of 68-69ºC, a boiling point of 462.0±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 233.2±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 243984-11-4
Jingsj CID: J-1963197-1
Molecular Formula: C₁₅H₁₇ClFNO₄S
Molecular Weight: 361.816 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	68-69ºC
Boiling Point	462.0±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	233.2±31.5 °C
Exact Mass	361.055084
PSA	80.85000
LogP	3.58
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.574
Storage Conditions	2-8℃

Activity & Biological Data

Target	TLR4[1]
Additional Information	[1]. Ii M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. [2]. Ni JQ, et al. Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE?/? mice. Clin Dev Immunol. 2013;2013:476856. [3]. Gárate I, et al. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress. J Neuroinflammation. 2014 Jan 11;11:8. [4]. Wang L, et al. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res. 2016 Nov 15;76(22):6631-6642. [5]. Shibata A, et al. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA. J Autoimmun. 2017 Jun;80:28-38. [6]. Janda J, et al. Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol. 2016 Nov;92(6):816-825. [7]. Krock E, et al. Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model. Osteoarthritis Cartilage. 2018 Sep;26(9):1236-1246.

Target

TLR4[1]

Additional Information

[1]. Ii M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. [2]. Ni JQ, et al. Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE?/? mice. Clin Dev Immunol. 2013;2013:476856. [3]. Gárate I, et al. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress. J Neuroinflammation. 2014 Jan 11;11:8. [4]. Wang L, et al. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res. 2016 Nov 15;76(22):6631-6642. [5]. Shibata A, et al. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA. J Autoimmun. 2017 Jun;80:28-38. [6]. Janda J, et al. Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol. 2016 Nov;92(6):816-825. [7]. Krock E, et al. Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model. Osteoarthritis Cartilage. 2018 Sep;26(9):1236-1246.

Frequently Asked Questions

What is the CAS number of Resatorvid?

The CAS number of Resatorvid is 243984-11-4.

What are the molecular formula and molecular weight of Resatorvid?

Resatorvid has molecular formula C15H17ClFNO4S and molecular weight 361.816 g/mol.

What are the upstream and downstream products of Resatorvid?

For Resatorvid, Upstream Products: Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate, ethyl 2-sulfanylcyclohex-1-ene-1-carboxylate, Ethyl 2-oxocyclohexanecarboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Resatorvid (CAS 243984-11-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963197-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.