Polyphyllin I

Also known as: Polyphyllin I, Paridis saponin I, Paris saponin Pa, Chonglou saponin I, β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1->4)-O-[6-deoxy-α-L-mannopyranosyl-(1->2)]-

Polyphyllin I (CAS 50773-41-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C44H70O16 and a molecular weight of 855.017 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 50773-41-6
Jingsj CID: J-1963137-9
Molecular Formula: C₄₄H₇₀O₁₆
Molecular Weight: 855.017 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	854.466370
PSA	235.68000
LogP	7.12
Refractive Index	1.618

Activity & Biological Data

Target	JNK signaling[2] PDK1/Akt/mTOR signaling[3]
Additional Information	[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33. [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486. [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

Target

JNK signaling[2] PDK1/Akt/mTOR signaling[3]

Additional Information

[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33. [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486. [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

Frequently Asked Questions

What is the CAS number of Polyphyllin I?

The CAS number of Polyphyllin I is 50773-41-6.

What are the molecular formula and molecular weight of Polyphyllin I?

Polyphyllin I has molecular formula C44H70O16 and molecular weight 855.017 g/mol.

What are the upstream and downstream products of Polyphyllin I?

For Polyphyllin I, Downstream Products: Trillin, Prosapogenin A, Diosgenin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Polyphyllin I (CAS 50773-41-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963137-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.