Vandetanib

Also known as: ZD6474, Zactima, Caprelsa, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine, 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline

Vandetanib (CAS 443913-73-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H24BrFN4O2 and a molecular weight of 475.354 g/mol. Key properties include a melting point of 240-243ºC, a boiling point of 538.2±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 279.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 443913-73-3
Jingsj CID: J-1963116-4
Molecular Formula: C₂₂H₂₄BrFN₄O₂
Molecular Weight: 475.354 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	240-243ºC
Boiling Point	538.2±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	279.3±30.1 °C
Exact Mass	474.106659
PSA	59.51000
LogP	5.51
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.629
Storage Conditions	-20?C Freezer

Activity & Biological Data

Target	VEGFR2:40 nM (IC50)
Additional Information	[1]. Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55. [2]. Hegedus C, et al. Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol. 2012 Aug 1;84(3):260-7. [3]. Takeda H, et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23. [4]. Inoue K, et al. Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33.

Target

VEGFR2:40 nM (IC50)

Additional Information

[1]. Wedge SR, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55. [2]. Hegedus C, et al. Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol. 2012 Aug 1;84(3):260-7. [3]. Takeda H, et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23. [4]. Inoue K, et al. Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Vandetanib?

The CAS number of Vandetanib is 443913-73-3.

What are the molecular formula and molecular weight of Vandetanib?

Vandetanib has molecular formula C22H24BrFN4O2 and molecular weight 475.354 g/mol.

What are the upstream and downstream products of Vandetanib?

For Vandetanib, Upstream Products: Formaldehyde, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-amine, tert-butyl 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vandetanib (CAS 443913-73-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963116-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.