Axitinib
Also known as: Inlyta, AG 013736, AG-013736, AG013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide, N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide, Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-, (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide, UNII-C9LVQ0YUXG
Axitinib (CAS 319460-85-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H18N4OS and a molecular weight of 386.470 g/mol. Key properties include a melting point of 213-215ºC, a boiling point of 668.9±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 358.3±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 319460-85-0
- Jingsj CID
- J-1963103-9
- Molecular Formula
- C22H18N4OS
- Molecular Weight
- 386.470 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 213-215ºC |
|---|---|
| Boiling Point | 668.9±55.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 358.3±31.5 °C |
| Exact Mass | 386.120117 |
| PSA | 95.97000 |
| LogP | 4.15 |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| Refractive Index | 1.728 |
| Storage Conditions | -20°C Freezer |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H400 — Very toxic to aquatic life
Activity & Biological Data
| Target | VEGFR1:0.1 nM (IC50) VEGFR2:0.2 nM (IC50) VEGFR3:0.1 nM (IC50) PDGFRβ:1.6 nM (IC50) |
|---|---|
| Additional Information | [1]. Fenton BM, et al. The addition of AG-013736 to rractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15;67(20):9921-8. [2]. Hu-Lowe DD, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83 [3]. Allen E, et al. Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 2016 May 10;15(6):1144-60. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Axitinib?
The CAS number of Axitinib is 319460-85-0.
What are the molecular formula and molecular weight of Axitinib?
Axitinib has molecular formula C22H18N4OS and molecular weight 386.470 g/mol.
Is Axitinib hazardous?
Axitinib has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H400 — Very toxic to aquatic life.
What are the upstream and downstream products of Axitinib?
For Axitinib, Upstream Products: 2-Vinylpyridine, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-methylbenzamide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Axitinib (CAS 319460-85-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1963103-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.