Betrixaban

Also known as: Betrixaban (USAN), PRT054021, MK-4448, MLN-1021, QCR-99, UNII-74RWP7W0J9, N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide

Betrixaban (CAS 330942-05-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H22ClN5O3 and a molecular weight of 451.905 g/mol. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 330942-05-7
Jingsj CID: J-1962494-3
Molecular Formula: C₂₃H₂₂ClN₅O₃
Molecular Weight: 451.905 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.3±0.1 g/cm3
Exact Mass	451.141113
PSA	110.90000
LogP	2.93
Appearance	light yellow solid
Refractive Index	1.629
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: 1.5 nM (fXa)[1] Ki: 0.117 nM (fXa), 1.8 μM (hERG)[1]
Additional Information	[1]. Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21 [2]. Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51.

Target

IC50: 1.5 nM (fXa)[1] Ki: 0.117 nM (fXa), 1.8 μM (hERG)[1]

Additional Information

[1]. Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21 [2]. Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51.

Frequently Asked Questions

What is the CAS number of Betrixaban?

The CAS number of Betrixaban is 330942-05-7.

What are the molecular formula and molecular weight of Betrixaban?

Betrixaban has molecular formula C23H22ClN5O3 and molecular weight 451.905 g/mol.

What are the upstream and downstream products of Betrixaban?

For Betrixaban, Upstream Products: Dimethylamine, Lithium dimethylamide, N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Betrixaban (CAS 330942-05-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962494-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.