SRT 1720

Also known as: 2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-, N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide, N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide, N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide, SRT 1720, 10 mM in DMSO, SRT1720 - CAS 925434-55-5 - Calbiochem, SRT1720 free base/ STR1720 HCl salt

SRT 1720 (CAS 925434-55-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H23N7OS and a molecular weight of 469.56100 g/mol. Key properties include a melting point of 221ºC and a density of 1.46. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 925434-55-5
Jingsj CID: J-1962139-7
Molecular Formula: C₂₅H₂₃N₇OS
Molecular Weight: 469.56100 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	221ºC
Density	1.46
Exact Mass	469.16800
PSA	115.69000
LogP	4.00320

Activity & Biological Data

Target	SIRT1:0.16 μM (EC1.5) SIRT2:37 μM (EC1.5)
Additional Information	[1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 [2]. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 [3]. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. [4]. Yu L, et al. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11.

Target

SIRT1:0.16 μM (EC1.5) SIRT2:37 μM (EC1.5)

Additional Information

[1]. Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 [2]. Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan?,Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 [3]. Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.,J Clin Invest. 2012 Jun 1;122(6):2032-45. [4]. Yu L, et al. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11.

Customs & Trade Information

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Frequently Asked Questions

What is the CAS number of SRT 1720?

The CAS number of SRT 1720 is 925434-55-5.

What are the molecular formula and molecular weight of SRT 1720?

SRT 1720 has molecular formula C25H23N7OS and molecular weight 469.56100 g/mol.

What are the upstream and downstream products of SRT 1720?

For SRT 1720, Upstream Products: tert-Butyl 4-((6-(2-(quinoxaline-2-carboxamido)phenyl)imidazo[2,1-b]thiazol-3-yl)methyl)piperazine-1-carboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "SRT 1720 (CAS 925434-55-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1962139-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.