Temocaprilat

Also known as: (2S,6R)-6-[[(1S)-1-Carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic acid, (2S)-2-{[(2S,6R)-4-(Carboxymethyl)-5-oxo-2-(2-thienyl)-1,4-thiazepan-6-yl]amino}-4-phenylbutanoic acid, RS-5139, Temocapril Diacid, Temocaprilate, 1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-carboxy-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, (2S,6R)-, [3H]-Temocaprilat

Temocaprilat (CAS 110221-53-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H24N2O5S2 and a molecular weight of 448.556 g/mol. Key properties include a melting point of >230ºC (dec), a boiling point of 743.6±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 403.5±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 110221-53-9
Jingsj CID: J-1961820-3
Molecular Formula: C₂₁H₂₄N₂O₅S₂
Molecular Weight: 448.556 g/mol
Category: Organic Compounds
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	>230ºC (dec)
Boiling Point	743.6±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	403.5±32.9 °C
Exact Mass	448.112671
PSA	160.48000
LogP	3.51
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.665
Storage Conditions	-20°C

Activity & Biological Data

Additional Information	[1]. Yasunari K, et al. Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S55-60. [2]. Püchler K, et al. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. Br J Clin Pharmacol. 1998 Oct;46(4):363-7. [3]. Ito N, et al. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am J Hypertens. 2007 Jul;20(7):792-9. [4]. Yang Z H, et al. P-540: Olmesartan and temocaprilat suppress IL-1 [beta]-induced IL-6 expression via a decrease in mRNA stability in vascular smooth muscle cells[J]. American Journal of Hypertension, 2002, 15(S3): 228A.

Additional Information

[1]. Yasunari K, et al. Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S55-60. [2]. Püchler K, et al. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. Br J Clin Pharmacol. 1998 Oct;46(4):363-7. [3]. Ito N, et al. Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats. Am J Hypertens. 2007 Jul;20(7):792-9. [4]. Yang Z H, et al. P-540: Olmesartan and temocaprilat suppress IL-1 [beta]-induced IL-6 expression via a decrease in mRNA stability in vascular smooth muscle cells[J]. American Journal of Hypertension, 2002, 15(S3): 228A.

Frequently Asked Questions

What is the CAS number of Temocaprilat?

The CAS number of Temocaprilat is 110221-53-9.

What are the molecular formula and molecular weight of Temocaprilat?

Temocaprilat has molecular formula C21H24N2O5S2 and molecular weight 448.556 g/mol.

What are the upstream and downstream products of Temocaprilat?

For Temocaprilat, Upstream Products: Temocapril (hydrochloride), (E)-2-(2-Nitroethenyl)thiophene, (R)-2-Hydroxy-4-phenylbutyric acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Temocaprilat (CAS 110221-53-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1961820-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.