Neratinib
Also known as: HKI-272, HKI 272, HKI272, (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide, (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide, PB-272, WAY-179272
Neratinib (CAS 698387-09-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H29ClN6O3 and a molecular weight of 557.043 g/mol. Key properties include a melting point of 184 °C, a boiling point of 757.0±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 411.6±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 698387-09-6
- Jingsj CID
- J-1961711-9
- Molecular Formula
- C30H29ClN6O3
- Molecular Weight
- 557.043 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 184 °C |
|---|---|
| Boiling Point | 757.0±60.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 411.6±32.9 °C |
| Exact Mass | 556.198975 |
| PSA | 112.40000 |
| LogP | 5.46 |
| Vapor Pressure | 0.0±2.5 mmHg at 25°C |
| Refractive Index | 1.667 |
Activity & Biological Data
| Target | EGFR:92 nM (IC50) HER2:59 nM (IC50) |
|---|---|
| Additional Information | [1]. Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965. [2]. Yoshioka T, et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr;109(4):1166-1176. |
Frequently Asked Questions
What is the CAS number of Neratinib?
The CAS number of Neratinib is 698387-09-6.
What are the molecular formula and molecular weight of Neratinib?
Neratinib has molecular formula C30H29ClN6O3 and molecular weight 557.043 g/mol.
What are the upstream and downstream products of Neratinib?
For Neratinib, Upstream Products: 6-amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile, (E)-4-(dimethylamino)but-2-enoyl chloride hydrochloride, 3-Chloro-4-(pyridin-2-ylmethoxy)aniline.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Neratinib (CAS 698387-09-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1961711-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.