Lomeguatrib
Also known as: PaTrin-2, 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine, 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine, 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine, CHEMBL339133, UNII-S79265T71M, S792, 7H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-, C521206
Lomeguatrib (CAS 192441-08-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H8BrN5OS and a molecular weight of 326.172 g/mol. Key properties include a boiling point of 683.8±65.0 °C at 760 mmHg, a density of 1.9±0.1 g/cm3 and a flash point of 367.3±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 192441-08-0
- Jingsj CID
- J-1961665-0
- Molecular Formula
- C10H8BrN5OS
- Molecular Weight
- 326.172 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 683.8±65.0 °C at 760 mmHg |
|---|---|
| Density | 1.9±0.1 g/cm3 |
| Flash Point | 367.3±34.3 °C |
| Exact Mass | 324.963287 |
| PSA | 117.95000 |
| LogP | 2.36 |
| Appearance | white to beige |
| Vapor Pressure | 0.0±2.1 mmHg at 25°C |
| Refractive Index | 1.797 |
| Storage Conditions | room temp |
| Additional Property | DMSO: soluble10mg/mL, clear |
GHS Safety & Compliance
- H302 — Harmful if swallowed
Activity & Biological Data
| Target | MGMT:6 nM (IC50, in MCF-7 cells) MGMT:9 nM (IC50) |
|---|---|
| Additional Information | [1]. Reinhard J, et al. Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J Med Chem. 2001 Nov 22;44(24):4050-61. [2]. Clemons M, et al. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br J Cancer. 2005 Nov 14;93(10):1152-6. |
Frequently Asked Questions
What is the CAS number of Lomeguatrib?
The CAS number of Lomeguatrib is 192441-08-0.
What are the molecular formula and molecular weight of Lomeguatrib?
Lomeguatrib has molecular formula C10H8BrN5OS and molecular weight 326.172 g/mol.
Is Lomeguatrib hazardous?
Lomeguatrib has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.
What are the upstream and downstream products of Lomeguatrib?
For Lomeguatrib, Upstream Products: (4-Bromothiophen-2-yl)methanol, 4-Bromothiophene-2-carboxaldehyde.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Lomeguatrib (CAS 192441-08-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1961665-0 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.