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Raloxifene hydrochloride

Also known as: LY 156758, Keoxifene hydrochloride, Evista, LY139481 hydrochloride, Raloxifene HCl, Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride (1:1), 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone hydrochloride, Raloxifene (hydrochloride), Bonebay, Bontact, Fiona, Optruma, Ralista, Ralofen, Reloxafine

Raloxifene hydrochloride (CAS 82640-04-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C28H28ClNO4S and a molecular weight of 510.044 g/mol. Key properties include a melting point of 143-147ºC, a boiling point of 728.2ºC at 760 mmHg, a density of 1.285g/cm3 and a flash point of 394.2ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
82640-04-8
Jingsj CID
J-1961202-3
Molecular Formula
C28H28ClNO4S
Molecular Weight
510.044 g/mol
Category
Organic Acids
Last updated
8/21/2026

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Physicochemical Properties

Melting Point143-147ºC
Boiling Point728.2ºC at 760 mmHg
Density1.285g/cm3
Flash Point394.2ºC
Exact Mass509.142761
PSA98.24000
LogP6.81510
Refractive Index1.654
Storage Conditions-20°C Freezer
Additional PropertyDMSO: 28 mg/mL, soluble

Activity & Biological Data

Additional Information[1]. Yang, N.N., et al., Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology, 1996. 137(5): p. 2075-84. [2]. Obach, R.S., Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos, 2004. 32(1): p. 89-97. [3]. Sato, M., M.K. Rippy, and H.U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J, 1996. 10(8): p. 905-12. [4]. Black, L.J., et al., Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest, 1994. 93(1): p. 63-9. [5]. Evans, G., et al., The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology, 1994. 134(5): p. 2283-8.

Frequently Asked Questions

What is the CAS number of Raloxifene hydrochloride?

The CAS number of Raloxifene hydrochloride is 82640-04-8.

What are the molecular formula and molecular weight of Raloxifene hydrochloride?

Raloxifene hydrochloride has molecular formula C28H28ClNO4S and molecular weight 510.044 g/mol.

What are the upstream and downstream products of Raloxifene hydrochloride?

For Raloxifene hydrochloride, Upstream Products: 2-[4-(acetyloxy)phenyl]benzo[b]thiophene-6-ol acetate, 4-[2-(1-Piperidinyl)ethoxy]benzoic acid hydrochloride, Raloxifene Bismethyl Ether hydrochloride; Downstream Products: Raloxifene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Raloxifene hydrochloride (CAS 82640-04-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1961202-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.