Asenapine maleate

Also known as: (3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate, (3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate (1:1), 1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole,5-chloro-2,3,3a,12b-tetrahydro-2-methyl-,(3aR,12bR)-rel-,(2Z)-2-butenedioate (1:1), 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aS,12bS)-, (2Z)-2-butenedioate (1:1), 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, trans-, (Z)-2-butenedioate (1:1), Asenapine, Asenapine maleate, Org 5222, Org 5222 Maleate, Saphris, Sycrest, trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate, trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate, trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate, trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate, trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oxepino[4,5-C]pyrrolidino maleate

Asenapine maleate (CAS 85650-56-2) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C21H20ClNO5 and a molecular weight of 401.84000 g/mol. Key properties include a melting point of 141-145°, a boiling point of 357.9ºC at 760 mmHg and a flash point of 170.2ºC. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 85650-56-2
Jingsj CID: J-1960495-6
Molecular Formula: C₂₁H₂₀ClNO₅
Molecular Weight: 401.84000 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	141-145°
Boiling Point	357.9ºC at 760 mmHg
Flash Point	170.2ºC
Exact Mass	401.10300
PSA	87.07000
LogP	3.90820
Storage Conditions	2-8°C
Additional Property	H2O: ≥10mg/mL

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs

Activity & Biological Data

Target	5-HT1A Receptor:2.5 nM (Ki) 5-HT2A Receptor:0.06 nM (Ki) 5-HT2C Receptor:0.03 nM (Ki) 5-HT7 Receptor:0.13 nM (Ki) D2 Receptor:1.3 nM (Ki) D3 Receptor:0.42 nM (Ki) D4 Receptor:1.1 nM (Ki)
Additional Information	[1]. Stoner SC, et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [3]. Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. [4]. Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91.

Target

5-HT1A Receptor:2.5 nM (Ki) 5-HT2A Receptor:0.06 nM (Ki) 5-HT2C Receptor:0.03 nM (Ki) 5-HT7 Receptor:0.13 nM (Ki) D2 Receptor:1.3 nM (Ki) D3 Receptor:0.42 nM (Ki) D4 Receptor:1.1 nM (Ki)

Additional Information

[1]. Stoner SC, et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [3]. Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. [4]. Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91.

Frequently Asked Questions

What is the CAS number of Asenapine maleate?

The CAS number of Asenapine maleate is 85650-56-2.

What are the molecular formula and molecular weight of Asenapine maleate?

Asenapine maleate has molecular formula C21H20ClNO5 and molecular weight 401.84000 g/mol.

Is Asenapine maleate hazardous?

Asenapine maleate has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of Asenapine maleate?

For Asenapine maleate, Upstream Products: Asenapine, Maleic acid, 2-Chlorophenylacetic acid; Downstream Products: Asenapine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Asenapine maleate (CAS 85650-56-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1960495-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.