6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione

Also known as: Licostinel, ACEA-1021, CGP 63446, 1,4-dihydro-6,7-dichloro-5-nitroquinoxaline-2,3-dione, 2,3-Quinoxalinedione, 6,7-dichloro-1,4-dihydro-5-nitro-, 5-Nitro-6,7-dichloro-2,3-quinoxalinedione, 6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione, 6,7-Dichloro-5-nitro-2,3-quinoxalinedione, 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione

6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione (CAS 153504-81-5) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C8H3Cl2N3O4 and a molecular weight of 276.03 g/mol. Key property: a density of 1.757g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 153504-81-5
Jingsj CID: J-1960338-0
Molecular Formula: C₈H₃Cl₂N₃O₄
Molecular Weight: 276.03 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.757g/cm3
Exact Mass	274.95000
PSA	111.54000
LogP	1.95460
Refractive Index	1.647

Activity & Biological Data

Target	59 nM (glycine receptor)[1]
Additional Information	[1]. Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. [2]. Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30(3):508-13. [3]. Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9.

Target

59 nM (glycine receptor)[1]

Additional Information

[1]. Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. [2]. Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30(3):508-13. [3]. Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9.

Frequently Asked Questions

What is the CAS number of 6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione?

The CAS number of 6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione is 153504-81-5.

What are the molecular formula and molecular weight of 6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione?

6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione has molecular formula C8H3Cl2N3O4 and molecular weight 276.03 g/mol.

What are the upstream and downstream products of 6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione?

For 6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione, Upstream Products: 6,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione, 2-Hydroxy-6,7-dichloroquinoxaline, 4,5-Dichloro-1,2-benzenediamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "6,7-Dichloro-5-nitroquinoxaline-2,3(1H,4H)-dione (CAS 153504-81-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1960338-0 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.