Guvacine hydrochloride

Also known as: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride, 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid hydrochloride, Guvacine hydrochloride, 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride, Norareca alkaloid hydrochloride

Guvacine hydrochloride (CAS 6027-91-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C6H10ClNO2 and a molecular weight of 163.60200 g/mol. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6027-91-4
Jingsj CID: J-1960232-5
Molecular Formula: C₆H₁₀ClNO₂
Molecular Weight: 163.60200 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Exact Mass	163.04000
PSA	49.33000
LogP	1.12150
Storage Conditions	2-8℃

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	IC50: 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), 1870 μM (human BGT-3)[1]
Additional Information	[1]. Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. [2]. Krogsgaard-Larsen P, et al. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J Neurochem. 1978 Jun;30(6):1377-82. [3]. Lodge D, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

Target

IC50: 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), 1870 μM (human BGT-3)[1]

Additional Information

[1]. Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. [2]. Krogsgaard-Larsen P, et al. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J Neurochem. 1978 Jun;30(6):1377-82. [3]. Lodge D, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.

Customs & Trade Information

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Guvacine hydrochloride?

The CAS number of Guvacine hydrochloride is 6027-91-4.

What are the molecular formula and molecular weight of Guvacine hydrochloride?

Guvacine hydrochloride has molecular formula C6H10ClNO2 and molecular weight 163.60200 g/mol.

Is Guvacine hydrochloride hazardous?

Guvacine hydrochloride has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Guvacine hydrochloride?

For Guvacine hydrochloride, Upstream Products: Arecoline hydrobromide; Downstream Products: 1-(tert-Butoxycarbonyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Guvacine hydrochloride (CAS 6027-91-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1960232-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.