PHA-767491

Also known as: 1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one, 2-(4-Pyridinyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one, 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

PHA-767491 (CAS 845714-00-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C12H11N3O and a molecular weight of 213.24 g/mol. Key properties include a boiling point of 620.6ºC at 760 mmHg, a density of 1.287 and a flash point of 329.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 845714-00-3
Jingsj CID: J-1959965-6
Molecular Formula: C₁₂H₁₁N₃O
Molecular Weight: 213.24 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	620.6ºC at 760 mmHg
Density	1.287
Flash Point	329.1ºC
PSA	57.78000
LogP	2.49340
Storage Conditions	Desiccate at RT

Activity & Biological Data

Target	CDK9:34 nM (IC50) CDK2:240 nM (IC50) CDK1:250 nM (IC50) CDK5:460 nM (IC50) GSK3-β:220 nM (IC50) Mk2:470 nM (IC50) Plk1:980 nM (IC50) Chk2:1100 nM (IC50)
Additional Information	[1]. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. [2]. Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204. [3]. Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88. [4]. Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.

Target

CDK9:34 nM (IC50) CDK2:240 nM (IC50) CDK1:250 nM (IC50) CDK5:460 nM (IC50) GSK3-β:220 nM (IC50) Mk2:470 nM (IC50) Plk1:980 nM (IC50) Chk2:1100 nM (IC50)

Additional Information

[1]. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. [2]. Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15(3):196-204. [3]. Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88. [4]. Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4(6):357-65.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of PHA-767491?

The CAS number of PHA-767491 is 845714-00-3.

What are the molecular formula and molecular weight of PHA-767491?

PHA-767491 has molecular formula C12H11N3O and molecular weight 213.24 g/mol.

What are the upstream and downstream products of PHA-767491?

For PHA-767491, Upstream Products: 2-(Bromoacetyl)pyridine hydrobromide, Piperidine-2,4-dione, 4-(Bromoacetyl)pyridine hydrobromide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "PHA-767491 (CAS 845714-00-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959965-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.