Withaferin A

Also known as: Withaferin A, Withaferine, NSC 273757, (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone, (20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta-2,24-dien-26-oic Acid δ-Lactone

Withaferin A (CAS 5119-48-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H38O6 and a molecular weight of 470.598 g/mol. Key properties include a melting point of 252-253ºC, a boiling point of 680.7±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 226.7±25.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 5119-48-2
Jingsj CID: J-1959919-0
Molecular Formula: C₂₈H₃₈O₆
Molecular Weight: 470.598 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	252-253ºC
Boiling Point	680.7±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	226.7±25.0 °C
Exact Mass	470.266846
PSA	96.36000
LogP	3.80
Vapor Pressure	0.0±4.8 mmHg at 25°C
Refractive Index	1.599
Storage Conditions	2-8°C

Activity & Biological Data

Target	NFκB
Additional Information	[1]. Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6. [2]. Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34. [3]. Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.

Target

NFκB

Additional Information

[1]. Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6. [2]. Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34. [3]. Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.

Frequently Asked Questions

What is the CAS number of Withaferin A?

The CAS number of Withaferin A is 5119-48-2.

What are the molecular formula and molecular weight of Withaferin A?

Withaferin A has molecular formula C28H38O6 and molecular weight 470.598 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Withaferin A (CAS 5119-48-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959919-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.