PHA-665752 hydrate

Also known as: (3Z)-5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-1H-pyrrol-2-yl]methylene]-1,3-dihydro-2H-indol-2-one, PHA 665752, PHA665752, (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine, (R,Z)-5-((2,6-Dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one

PHA-665752 hydrate (CAS 477575-56-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C32H34Cl2N4O4S and a molecular weight of 641.608 g/mol. Key properties include a boiling point of 890.2±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 492.2±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 477575-56-7
Jingsj CID: J-1959911-2
Molecular Formula: C₃₂H₃₄Cl₂N₄O₄S
Molecular Weight: 641.608 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	890.2±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	492.2±34.3 °C
Exact Mass	640.167786
PSA	110.96000
LogP	4.00
Appearance	light yellow to light brown
Vapor Pressure	0.0±0.3 mmHg at 25°C
Refractive Index	1.656
Storage Conditions	Store at +4°C
Additional Property	DMSO: ≥20mg/mL

Activity & Biological Data

Additional Information	[1]. Christensen JG, et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res, 2003, 63(21), 7345-7355. [2]. Ma PC, et al. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin Cancer Res, 2005, 11(6), 2312-2319. [3]. Puri N, et al. A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Cancer Res, 2007, 67(8), 3529-3534. [4]. Tsubaki M, et al. Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells. Oncotarget. 2017 Jun 13;8(24):38717-38730.

Additional Information

[1]. Christensen JG, et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res, 2003, 63(21), 7345-7355. [2]. Ma PC, et al. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin Cancer Res, 2005, 11(6), 2312-2319. [3]. Puri N, et al. A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Cancer Res, 2007, 67(8), 3529-3534. [4]. Tsubaki M, et al. Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells. Oncotarget. 2017 Jun 13;8(24):38717-38730.

Frequently Asked Questions

What is the CAS number of PHA-665752 hydrate?

The CAS number of PHA-665752 hydrate is 477575-56-7.

What are the molecular formula and molecular weight of PHA-665752 hydrate?

PHA-665752 hydrate has molecular formula C32H34Cl2N4O4S and molecular weight 641.608 g/mol.

What are the upstream and downstream products of PHA-665752 hydrate?

For PHA-665752 hydrate, Upstream Products: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "PHA-665752 hydrate (CAS 477575-56-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959911-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.