Necrostatin-1
Also known as: 4-Imidazolidinone, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxoimidazolidin-4-one, 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one, 5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN, 5-indol-3-ylmethyl-3-methyl-2-thioxo-imidazolidin-4-one, CS-959, IFLAB-BB F0911-6127, MTH-DL-TRYPTOPHAN, MTH-DL-Tryptophan, MTH-trp, NECROSTATIN 1, NECROSTATIN1, Nec-1, Necroptotic Inhibitor,Nec-1, Necrostatin 1, Necrostatin-1 - CAS 4311-88-0 - Calbiochem, Necrostatin-1, >=98%, methyl-thiohydantoin-tryptophan
Necrostatin-1 (CAS 4311-88-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H13N3OS and a molecular weight of 259.327 g/mol. Key properties include a melting point of 151ºC, a boiling point of 441.9±37.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 221.1±26.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 4311-88-0
- Jingsj CID
- J-1959877-7
- Molecular Formula
- C13H13N3OS
- Molecular Weight
- 259.327 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 151ºC |
|---|---|
| Boiling Point | 441.9±37.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 221.1±26.5 °C |
| Exact Mass | 259.077942 |
| PSA | 80.22000 |
| LogP | 1.26 |
| Appearance | solid |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 1.738 |
| Storage Conditions | −20°C |
| Additional Property | DMSO: >10 mg/mL |
Activity & Biological Data
| Target | RIP1 kinase[1] |
|---|---|
| Additional Information | [1]. Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9. [2]. Linkermann A, et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013 Oct;24(10):1545-57. [3]. Huang C, et al. Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS One. 2013 Jun 28;8(6):e66326. [4]. Feyen D, et al. Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function. Cardiovasc Res. 2013 Jul 1;99(1):83-91. [5]. Zhou K, et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Necrostatin-1?
The CAS number of Necrostatin-1 is 4311-88-0.
What are the molecular formula and molecular weight of Necrostatin-1?
Necrostatin-1 has molecular formula C13H13N3OS and molecular weight 259.327 g/mol.
What are the upstream and downstream products of Necrostatin-1?
For Necrostatin-1, Upstream Products: Methyl isothiocyanate, DL-Tryptophan.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Necrostatin-1 (CAS 4311-88-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959877-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.