Novobiocin
Also known as: Streptonivicin, Cardelmycin, Inamycin, Albamycin, Spheromycin, Cathomycin, Cathocin, Crystallinic acid, Antibiotic PA-93, Albamix, Novo-R, Robiocina, Sirbiocina, Stilbiocina, PA-93, U 6391, C05080, NOVOBIOCIN
Novobiocin (CAS 303-81-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C31H36N2O11 and a molecular weight of 612.624 g/mol. Key properties include a melting point of 170-172°C (lit.), a boiling point of 848.2±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 466.8±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H317 — May cause an allergic skin reaction. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 303-81-1
- Jingsj CID
- J-1959851-7
- Molecular Formula
- C31H36N2O11
- Molecular Weight
- 612.624 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 170-172°C (lit.) |
|---|---|
| Boiling Point | 848.2±65.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 466.8±34.3 °C |
| Exact Mass | 612.231934 |
| PSA | 200.01000 |
| LogP | 2.37 |
| Vapor Pressure | 0.0±3.3 mmHg at 25°C |
| Refractive Index | 1.640 |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H317 — May cause an allergic skin reaction
Activity & Biological Data
| Target | HSP90 |
|---|---|
| Additional Information | [1]. Marcu MG, et al. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 2000 Nov 24;275(47):37181-6. [2]. Ali-Osman F, et al. Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. Cancer Res. 1993 Dec 1;53(23):5663-8. [3]. Rodríguez-Cerrato V, et al. Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci. Int J Antimicrob Agents. 2010 Jun;35(6):544-9. [4]. Eder JP, et al. A phase I clinical trial of novobiocin, a modulator of alkylating agent cytotoxicity. Cancer Res. 1991 Jan 15;51(2):510-3. [5]. Bhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320. [6]. Smee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19(3):115-24. [7]. Smee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19(3):115-24. |
Frequently Asked Questions
What is the CAS number of Novobiocin?
The CAS number of Novobiocin is 303-81-1.
What are the molecular formula and molecular weight of Novobiocin?
Novobiocin has molecular formula C31H36N2O11 and molecular weight 612.624 g/mol.
Is Novobiocin hazardous?
Novobiocin has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H317 — May cause an allergic skin reaction.
What are the upstream and downstream products of Novobiocin?
For Novobiocin, Upstream Products: Novobiocin sodium salt; Downstream Products: COUMERMYCIN AL.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Novobiocin (CAS 303-81-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959851-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.