6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride

Also known as: SAR407899 hydrochloride, SAR 407899, SAR-407899, SAR407899 HCl, 6-piperidin-4-yloxy-2H-isoquinolin-1-one hydrochloride, qc-9996, CS-2364

6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride (CAS 923262-96-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C14H17ClN2O2 and a molecular weight of 280.75000 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 923262-96-8
Jingsj CID: J-1959404-8
Molecular Formula: C₁₄H₁₇ClN₂O₂
Molecular Weight: 280.75000 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	280.09800
PSA	54.12000
LogP	2.78970

Activity & Biological Data

Target	ROCK-2:102 nM (IC50) ROCK-1:276 nM (IC50)
Additional Information	[1]. L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. [2]. Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. [3]. Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7.

Target

ROCK-2:102 nM (IC50) ROCK-1:276 nM (IC50)

Additional Information

[1]. L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. [2]. Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. [3]. Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride?

The CAS number of 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride is 923262-96-8.

What are the molecular formula and molecular weight of 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride?

6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride has molecular formula C14H17ClN2O2 and molecular weight 280.75000 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride (CAS 923262-96-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959404-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.