Netupitant

Also known as: Netupitan, Ro 67-31898, Ro 67-31898/000, UNII-7732P08TIR, 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide, Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-

Netupitant (CAS 290297-26-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C30H32F6N4O and a molecular weight of 578.592 g/mol. Key properties include a boiling point of 597.4±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 315.1±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 290297-26-6
Jingsj CID: J-1959093-3
Molecular Formula: C₃₀H₃₂F₆N₄O
Molecular Weight: 578.592 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	597.4±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	315.1±30.1 °C
Exact Mass	578.248047
PSA	39.68000
LogP	6.39
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.540
Storage Conditions	-20℃

Activity & Biological Data

Additional Information	[1]. Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5. [2]. Stathis M, et al. Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30. [3]. Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97. [4]. Ajit G. Thomas, et al. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014; 232(8): 2637–2644.

Additional Information

[1]. Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5. [2]. Stathis M, et al. Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects. Eur J Pharmacol. 2012 Aug 15;689(1-3):25-30. [3]. Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97. [4]. Ajit G. Thomas, et al. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014; 232(8): 2637–2644.

Frequently Asked Questions

What is the CAS number of Netupitant?

The CAS number of Netupitant is 290297-26-6.

What are the molecular formula and molecular weight of Netupitant?

Netupitant has molecular formula C30H32F6N4O and molecular weight 578.592 g/mol.

What are the upstream and downstream products of Netupitant?

For Netupitant, Upstream Products: N-Methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine, 6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide, Methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Netupitant (CAS 290297-26-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959093-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.