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2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide

Also known as: CP-724714, CP724714, CP-724714 (E-Double bond), (E)-2-Methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide, E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide, 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide, 2-Methoxy-N-{(2E)-3-[4-({3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl}amino)-6-quinazolinyl]-2-propen-1-yl}acetamide, Acetamide, 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-, CP 724, 714

2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide (CAS 383432-38-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C27H27N5O3 and a molecular weight of 469.535 g/mol. Key properties include a boiling point of 687.3±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 369.5±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
383432-38-0
Jingsj CID
J-1959078-9
Molecular Formula
C27H27N5O3
Molecular Weight
469.535 g/mol
Category
Pharma Intermediates
Last updated
8/21/2026
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Physicochemical Properties

Boiling Point687.3±55.0 °C at 760 mmHg
Density1.3±0.1 g/cm3
Flash Point369.5±31.5 °C
Exact Mass469.211395
PSA98.26000
LogP4.05
Vapor Pressure0.0±2.1 mmHg at 25°C
Refractive Index1.663
Storage Conditions2-8℃

Activity & Biological Data

TargetErbB2:10 nM (IC50)
Additional Information[1]. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893. [2]. Feng B, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci, 2009, 108(2), 492-500.

Frequently Asked Questions

What is the CAS number of 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide?

The CAS number of 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide is 383432-38-0.

What are the molecular formula and molecular weight of 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide?

2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide has molecular formula C27H27N5O3 and molecular weight 469.535 g/mol.

What are the upstream and downstream products of 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide?

For 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide, Upstream Products: 6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine, 3-Hydroxy-6-methylpyridine, 2-Chloro-5-nitrotoluene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide (CAS 383432-38-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959078-9 (accessed 2026-11-06).

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