Timiperone

Also known as: Timeperone, Tolopelon, DD-3480, DD 3480, DTTB, 1-[1-[3-(4-Fluorobenzoyl)propyl]-4-piperidyl]-1H-benzimidazole-2(3H)-thione, 1-[1-[3-(p-Fluorobenzoyl)propyl]-4-piperidyl]-1H-benzimidazole-2(3H)-thione, 4'-Fluoro-γ-[4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)piperidino]butyrophenone, 4-[4-(2,3-Dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 1-(4-Fluorophenyl)-4-[4-(2-thioxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one

Timiperone (CAS 57648-21-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H24FN3OS and a molecular weight of 397.50900 g/mol. Key properties include a melting point of 201-203ºC, a boiling point of 560.8ºC at 760 mmHg, a density of 1.31 and a flash point of 293ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57648-21-2
Jingsj CID: J-1959047-7
Molecular Formula: C₂₂H₂₄FN₃OS
Molecular Weight: 397.50900 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	201-203ºC
Boiling Point	560.8ºC at 760 mmHg
Density	1.31
Flash Point	293ºC
Exact Mass	397.16200
PSA	73.12000
LogP	5.07590
Refractive Index	1.664

Activity & Biological Data

Target	dopamine D2 receptor[3]
Additional Information	[1]. Sudo K, et al. Disposition of timiperone, 4'-fluoro-4-[4-(2-thioxo-1-benzimidazolinyl)piperidino]butyrophenone, a neuroleptic, in the rat on repeated oral dosage. Xenobiotica. 1981 Oct;11(10):685-91. [2]. Kariya T, et al. A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique. J Int Med Res. 1983;11(2):66-77. [3]. Inada, K., et al. First-Generation Antipsychotics as a Bridge to Second-Generation Antipsychotics in the Japanese Pharmaceutical Industry: Mosapramine, Timiperone, Zotepine, and Nemonapride. NeuroPsychopharmacotherapy. Springer, Cham. (2021).

Target

dopamine D2 receptor[3]

Additional Information

[1]. Sudo K, et al. Disposition of timiperone, 4'-fluoro-4-[4-(2-thioxo-1-benzimidazolinyl)piperidino]butyrophenone, a neuroleptic, in the rat on repeated oral dosage. Xenobiotica. 1981 Oct;11(10):685-91. [2]. Kariya T, et al. A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique. J Int Med Res. 1983;11(2):66-77. [3]. Inada, K., et al. First-Generation Antipsychotics as a Bridge to Second-Generation Antipsychotics in the Japanese Pharmaceutical Industry: Mosapramine, Timiperone, Zotepine, and Nemonapride. NeuroPsychopharmacotherapy. Springer, Cham. (2021).

Frequently Asked Questions

What is the CAS number of Timiperone?

The CAS number of Timiperone is 57648-21-2.

What are the molecular formula and molecular weight of Timiperone?

Timiperone has molecular formula C22H24FN3OS and molecular weight 397.50900 g/mol.

What are the upstream and downstream products of Timiperone?

For Timiperone, Upstream Products: 4-Chloropyridine hydrochloride, o-Phenylenediamine, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Timiperone (CAS 57648-21-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1959047-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.