Triciribine

Also known as: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine, API-2, Akt/PKB Signaling Inhibitor-2, AKT INHIBITOR V, NSC 154020, 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine, UNII-2421HMY9N6

Triciribine (CAS 35943-35-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C13H16N6O4 and a molecular weight of 320.304 g/mol. Key properties include a boiling point of 718.5±70.0 °C at 760 mmHg, a density of 2.0±0.1 g/cm3 and a flash point of 388.3±35.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 35943-35-2
Jingsj CID: J-1958951-6
Molecular Formula: C₁₃H₁₆N₆O₄
Molecular Weight: 320.304 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	718.5±70.0 °C at 760 mmHg
Density	2.0±0.1 g/cm3
Flash Point	388.3±35.7 °C
Exact Mass	320.123291
PSA	144.47000
LogP	-2.70
Appearance	tan
Vapor Pressure	0.0±2.4 mmHg at 25°C
Refractive Index	1.928
Storage Conditions	Store at RT
Additional Property	DMSO: >10mg/mL

Activity & Biological Data

Target	DNA synthesis Akt:130 nM (IC50, Cell Assay) HIV-1:0.02-0.46 μM (IC50) HIV-2:0.02-0.46 μM (IC50)
Additional Information	[1]. Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125(4):932-41. [2]. Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies. Neuro Oncol. 2011 Jun;13(6):610-21. [3]. Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14. [4]. Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.

Target

DNA synthesis Akt:130 nM (IC50, Cell Assay) HIV-1:0.02-0.46 μM (IC50) HIV-2:0.02-0.46 μM (IC50)

Additional Information

[1]. Dieterle A, et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125(4):932-41. [2]. Gürsel DB, et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies. Neuro Oncol. 2011 Jun;13(6):610-21. [3]. Kucera LS, et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14. [4]. Abdalla M, et al. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.

Frequently Asked Questions

What is the CAS number of Triciribine?

The CAS number of Triciribine is 35943-35-2.

What are the molecular formula and molecular weight of Triciribine?

Triciribine has molecular formula C13H16N6O4 and molecular weight 320.304 g/mol.

What are the upstream and downstream products of Triciribine?

For Triciribine, Upstream Products: beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate, 4-amino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Triciribine (CAS 35943-35-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958951-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.