Methotrexate γ-Methyl Ester

Also known as: Methotrexate EP Impurity H, Methotrexate Impurity H, Methotrexate γ-Methyl Ester (Impurity H), Methotrexate-5-monomethyl ester, Methotrexate 5-methyl ester, Methotrexate Impurity 8 (EP-H), Methotrexate related compound H, Methotrexate specified impurity H [EP], (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-methoxy-5-oxopentanoic acid, L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, 5-methyl ester

Methotrexate γ-Methyl Ester (CAS 67022-39-3) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C21H24N8O5 and a molecular weight of 468.47 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 67022-39-3
Jingsj CID: J-1958629-0
Molecular Formula: C₂₁H₂₄N₈O₅
Molecular Weight: 468.47 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	468.18700
PSA	200.27000
LogP	1.25900

Activity & Biological Data

Additional Information	[1]. James J Fort, et al. Transport and degradation characteristics of methotrexate diallsyl ester prodrugs across tape-stripped hairless mouse skin. Int J Pharm. 1993, 100(1-3): 233-239.

Frequently Asked Questions

What is the CAS number of Methotrexate γ-Methyl Ester?

The CAS number of Methotrexate γ-Methyl Ester is 67022-39-3.

What are the molecular formula and molecular weight of Methotrexate γ-Methyl Ester?

Methotrexate γ-Methyl Ester has molecular formula C21H24N8O5 and molecular weight 468.47 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Methotrexate γ-Methyl Ester (CAS 67022-39-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958629-0 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.