4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide

Also known as: JNJ-7706621, JNJ 7706621, JNJ7706621, CS-409, Aurora Kinase/Cdk Inhibitor, Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide (CAS 443797-96-4) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C15H12F2N6O3S and a molecular weight of 394.356 g/mol. Key properties include a melting point of 149-155ºC, a boiling point of 676.6±65.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 363.0±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 443797-96-4
Jingsj CID: J-1958266-2
Molecular Formula: C₁₅H₁₂F₂N₆O₃S
Molecular Weight: 394.356 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	149-155ºC
Boiling Point	676.6±65.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3
Flash Point	363.0±34.3 °C
Exact Mass	394.065979
PSA	154.37000
LogP	0.18
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.724
Storage Conditions	-20℃
Additional Property	Soluble in DMSO at 15mg/ml

Activity & Biological Data

Target	CDK2/cyclinE:3 nM (IC50) cdk2/cyclin A:4 nM (IC50) Cdk1/cyclin B:9 nM (IC50) CDK3/Cyclin E:58 nM (IC50) CDK6/cyclinD1:175 nM (IC50) Cdk4/cyclin D1:253 nM (IC50) Aurora A:11 nM (IC50) Aurora B:15 nM (IC50) VEGF-R1:6400 nM (IC50) VEGF-R2:154 nM (IC50) VEGF-R3:735 nM (IC50) FGF-R1:575 nM (IC50) FGF-R2:226 nM (IC50) GSK3β:254 nM (IC50)
Additional Information	[1]. Huang S, et al. Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. Epub 2006 May 6. [2]. Matsuhashi A, et al. Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases. Curr Cancer Drug Targets. 2012 Jul;12(6):625-39. [3]. Danhier F, et al. Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor, JNJ-7706621. Int J Pharm. 2010 Jun 15;392(1-2):20-8. [4]. Emanuel S, et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 2005 Oct 1;65(19):9038-46.

Target

CDK2/cyclinE:3 nM (IC50) cdk2/cyclin A:4 nM (IC50) Cdk1/cyclin B:9 nM (IC50) CDK3/Cyclin E:58 nM (IC50) CDK6/cyclinD1:175 nM (IC50) Cdk4/cyclin D1:253 nM (IC50) Aurora A:11 nM (IC50) Aurora B:15 nM (IC50) VEGF-R1:6400 nM (IC50) VEGF-R2:154 nM (IC50) VEGF-R3:735 nM (IC50) FGF-R1:575 nM (IC50) FGF-R2:226 nM (IC50) GSK3β:254 nM (IC50)

Additional Information

[1]. Huang S, et al. Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. Epub 2006 May 6. [2]. Matsuhashi A, et al. Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases. Curr Cancer Drug Targets. 2012 Jul;12(6):625-39. [3]. Danhier F, et al. Active and passive tumor targeting of a novel poorly soluble cyclin dependent kinase inhibitor, JNJ-7706621. Int J Pharm. 2010 Jun 15;392(1-2):20-8. [4]. Emanuel S, et al. The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases. Cancer Res. 2005 Oct 1;65(19):9038-46.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide?

The CAS number of 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide is 443797-96-4.

What are the molecular formula and molecular weight of 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide?

4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide has molecular formula C15H12F2N6O3S and molecular weight 394.356 g/mol.

What are the upstream and downstream products of 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide?

For 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide, Upstream Products: 2,6-Difluorobenzoyl hydrazine, Diphenyl N-cyanocarbonimidate, Sulfanilamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide (CAS 443797-96-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958266-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.