Apabetalone

Also known as: RVX-208, RVX-000222, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(1H)-quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-1H-quinazolin-4-one

Apabetalone (CAS 1044870-39-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H22N2O5 and a molecular weight of 370.399 g/mol. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1044870-39-4
Jingsj CID: J-1958263-9
Molecular Formula: C₂₀H₂₂N₂O₅
Molecular Weight: 370.399 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.3±0.1 g/cm3
Exact Mass	370.152863
PSA	93.67000
LogP	2.04
Refractive Index	1.596
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: 510±41 nM (BD2), 87±10 μM (BD1)[1]
Additional Information	[1]. Picaud S, et al. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19754-9. [2]. McLure KG, et al. RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist. PLoS One. 2013 Dec 31;8(12):e83190. [3]. Jahagirdar R, et al. A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice. Atherosclerosis. 2014 Sep;236(1):91-100.

Target

IC50: 510±41 nM (BD2), 87±10 μM (BD1)[1]

Additional Information

[1]. Picaud S, et al. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19754-9. [2]. McLure KG, et al. RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist. PLoS One. 2013 Dec 31;8(12):e83190. [3]. Jahagirdar R, et al. A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice. Atherosclerosis. 2014 Sep;236(1):91-100.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Apabetalone?

The CAS number of Apabetalone is 1044870-39-4.

What are the molecular formula and molecular weight of Apabetalone?

Apabetalone has molecular formula C20H22N2O5 and molecular weight 370.399 g/mol.

What are the upstream and downstream products of Apabetalone?

For Apabetalone, Upstream Products: 4-(2-Hydroxyethoxy)-3,5-dimethylbenzaldehyde, 2-Amino-4,6-dimethoxybenzamide, 4,6-Dimethoxy-1H-indole-2,3-dione.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Apabetalone (CAS 1044870-39-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958263-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.