Rupatadine

Also known as: Rupatadine [INN], UR-12592, Rupafin, Rupafi, 8-chloro-11-[1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene]-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-11-{1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, UNII-2AE8M83G3E, MFCD00926499

Rupatadine (CAS 158876-82-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H26ClN3 and a molecular weight of 415.958 g/mol. Key properties include a melting point of 58-61ºC, a boiling point of 586.4±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 308.4±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 158876-82-5
Jingsj CID: J-1958252-6
Molecular Formula: C₂₆H₂₆ClN₃
Molecular Weight: 415.958 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	58-61ºC
Boiling Point	586.4±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	308.4±30.1 °C
Exact Mass	415.181519
PSA	29.02000
LogP	6.11
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.646
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21. [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60. [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.

Additional Information

[1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21. [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60. [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Rupatadine?

The CAS number of Rupatadine is 158876-82-5.

What are the molecular formula and molecular weight of Rupatadine?

Rupatadine has molecular formula C26H26ClN3 and molecular weight 415.958 g/mol.

What are the upstream and downstream products of Rupatadine?

For Rupatadine, Upstream Products: 3-(Bromomethyl)-5-methylpyridine, Desloratadine, 3,5-Dimethylpyridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rupatadine (CAS 158876-82-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1958252-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.