Allopregnanolone
Also known as: Brexanolone, 3α-Hydroxy-5α-pregnan-20-one, 5α-Pregnan-3α-ol-20-one, (3α)-Allopregnanolone, allopregnan-3α-ol-20-one, allotetrahydroprogesterone, 3α,5α-Tetrahydroprogesterone, 3α,5α-THP, 3α-OH-DHP, LJPC-0712, SAGE-547, Zulresso, (3α,5α)-3-Hydroxypregnan-20-one, 5α-Pregnane-3α-ol-20-one
Allopregnanolone (CAS 516-54-1) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C21H34O2 and a molecular weight of 318.493 g/mol. Key properties include a melting point of 176-178°, a boiling point of 431.2±18.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 183.9±13.8 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 516-54-1
- Jingsj CID
- J-1957895-4
- Molecular Formula
- C21H34O2
- Molecular Weight
- 318.493 g/mol
- Category
- Ketones
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 176-178° |
|---|---|
| Boiling Point | 431.2±18.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 183.9±13.8 °C |
| Exact Mass | 318.255890 |
| PSA | 37.30000 |
| LogP | 4.89 |
| Appearance | White solid |
| Vapor Pressure | 0.0±2.3 mmHg at 25°C |
| Refractive Index | 1.524 |
| Storage Conditions | Store at RT |
| Additional Property | chloroform: 20 mg/mL, clear, colorless |
Activity & Biological Data
| Target | Human Endogenous Metabolite |
|---|---|
| Additional Information | [1]. Wang JM, et al. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J Neurosci. 2005 May 11;25(19):4706-18. [2]. Giuliani FA, et al. Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3α-hydroxysteroid oxidoreductase in the hypothalamus of female rats. Neuroscience. 2013 Jul 23;243:64-75. [3]. Irwin RW, et al. Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease. PLoS One. 2015 Jun 3;10(6):e0128313. [4]. Irwin RW, et al. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Prog Neurobiol. 2014 Feb;113:40-55. [5]. Guennoun R, et al. Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection. J Steroid Biochem Mol Biol. 2015 Feb;146:48-61. |
Frequently Asked Questions
What is the CAS number of Allopregnanolone?
The CAS number of Allopregnanolone is 516-54-1.
What are the molecular formula and molecular weight of Allopregnanolone?
Allopregnanolone has molecular formula C21H34O2 and molecular weight 318.493 g/mol.
What are the upstream and downstream products of Allopregnanolone?
For Allopregnanolone, Downstream Products: 3α,21-dihydroxy-5α-pregnan-20-one, 5α-Androstane-3α,17β-diol, 5α-Dihydroprogesterone.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Allopregnanolone (CAS 516-54-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957895-4 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.