Danoprevir

Also known as: Danoprevir, ITMN-191, RG7227, R7227, RO5190591, (2R,6S,13aS,14aR,16aS,Z)-6-(((tert-butoxy)carbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-2,3,5,6,7,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa(e)pyrrolo[1,2-e][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate

Danoprevir (CAS 850876-88-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C35H46FN5O9S and a molecular weight of 731.831 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 850876-88-9
Jingsj CID: J-1957546-3
Molecular Formula: C₃₅H₄₆FN₅O₉S
Molecular Weight: 731.831 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	731.300049
PSA	199.37000
LogP	1.12
Refractive Index	1.622
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: 0.2-3.5 nM (NS3/4A protease)
Additional Information	[1]. Imhof I, et al. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191).Hepatology. 2011 Apr;53(4):1090-9. [2]. Seiwert, Scott D., et al. Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227). Antimicrobial Agents and Chemotherapy (2008), 52(12), 4432-4441. [3]. Bartels DJ, et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 2008 Sep 15;198(6):800-7.

Target

IC50: 0.2-3.5 nM (NS3/4A protease)

Additional Information

[1]. Imhof I, et al. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191).Hepatology. 2011 Apr;53(4):1090-9. [2]. Seiwert, Scott D., et al. Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227). Antimicrobial Agents and Chemotherapy (2008), 52(12), 4432-4441. [3]. Bartels DJ, et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 2008 Sep 15;198(6):800-7.

Frequently Asked Questions

What is the CAS number of Danoprevir?

The CAS number of Danoprevir is 850876-88-9.

What are the molecular formula and molecular weight of Danoprevir?

Danoprevir has molecular formula C35H46FN5O9S and molecular weight 731.831 g/mol.

What are the upstream and downstream products of Danoprevir?

For Danoprevir, Upstream Products: Cyclopropanesulfonamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Danoprevir (CAS 850876-88-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957546-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.