Dabrafenib
Also known as: Dabrafenib free base, GSK2118436, GSK2118436A, N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, CS-658, Tafinlar, UNII-QGP4HA4G1B, Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
Dabrafenib (CAS 1195765-45-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H20F3N5O2S2 and a molecular weight of 519.562 g/mol. Key properties include a boiling point of 653.7±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 349.2±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1195765-45-7
- Jingsj CID
- J-1957544-1
- Molecular Formula
- C23H20F3N5O2S2
- Molecular Weight
- 519.562 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 653.7±65.0 °C at 760 mmHg |
|---|---|
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 349.2±34.3 °C |
| Exact Mass | 519.101074 |
| PSA | 148.21000 |
| LogP | 3.54 |
| Vapor Pressure | 0.0±2.0 mmHg at 25°C |
| Refractive Index | 1.626 |
| Storage Conditions | -20°C |
Activity & Biological Data
| Target | BRafV600E:0.6 nM (IC50) CRAF:5 nM (IC50) |
|---|---|
| Additional Information | [1]. Greger JG, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther, 2012, 11(4), 909-920. [2]. Lee S, et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22. [3]. Jung B, et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. [4]. Alexander M Menzies, et al. Dabrafenib and its potential for the treatment of metastatic melanoma. Drug Des Devel Ther. 2012; 6: 391–405. [5]. Posobiec LM, et al. Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation. Birth Defects Res B Dev Reprod Toxicol. 2015 Dec;104(6):244-52. |
Frequently Asked Questions
What is the CAS number of Dabrafenib?
The CAS number of Dabrafenib is 1195765-45-7.
What are the molecular formula and molecular weight of Dabrafenib?
Dabrafenib has molecular formula C23H20F3N5O2S2 and molecular weight 519.562 g/mol.
What are the upstream and downstream products of Dabrafenib?
For Dabrafenib, Upstream Products: N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide, Methyl 3-amino-2-fluorobenzoate, Methyl 3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorobenzoate; Downstream Products: Dabrafenib Mesylate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Dabrafenib (CAS 1195765-45-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957544-1 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.