2'-deoxy-2'-fluoro-2'-C-methylcytidine

Also known as: PSI-6130, PSI6130, PSI 6130, R1656, R-1656, R 1656, 2'-Deoxy-2'-fluoro-2'-methylcytidine, 2'-Fluoro-2'-C-methylcytidine, Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one, (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine

2'-deoxy-2'-fluoro-2'-C-methylcytidine (CAS 817204-33-4) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H14FN3O4 and a molecular weight of 259.234 g/mol. Key properties include a boiling point of 482.4±55.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 245.5±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 817204-33-4
Jingsj CID: J-1957148-3
Molecular Formula: C₁₀H₁₄FN₃O₄
Molecular Weight: 259.234 g/mol
Category: Organohalogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	482.4±55.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3
Flash Point	245.5±31.5 °C
Exact Mass	259.096832
PSA	110.60000
LogP	-0.72
Vapor Pressure	0.0±2.7 mmHg at 25°C
Refractive Index	1.653

Activity & Biological Data

Target	IC50: 0.6 μM (HCV replication)[2]
Additional Information	[1]. Ali S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29812-20. Epub 2007 Aug 13.

Target

IC50: 0.6 μM (HCV replication)[2]

Additional Information

[1]. Ali S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29812-20. Epub 2007 Aug 13.

Frequently Asked Questions

What is the CAS number of 2'-deoxy-2'-fluoro-2'-C-methylcytidine?

The CAS number of 2'-deoxy-2'-fluoro-2'-C-methylcytidine is 817204-33-4.

What are the molecular formula and molecular weight of 2'-deoxy-2'-fluoro-2'-C-methylcytidine?

2'-deoxy-2'-fluoro-2'-C-methylcytidine has molecular formula C10H14FN3O4 and molecular weight 259.234 g/mol.

What are the upstream and downstream products of 2'-deoxy-2'-fluoro-2'-C-methylcytidine?

For 2'-deoxy-2'-fluoro-2'-C-methylcytidine, Upstream Products: (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate; Downstream Products: (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2'-deoxy-2'-fluoro-2'-C-methylcytidine (CAS 817204-33-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957148-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.