Afatinib

Also known as: BIBW 2992, BIBW-2992, Gilotrif, Tovok, Tomtovok, (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide, N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydrofuran-3-yl]oxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide

Afatinib (CAS 850140-72-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H25ClFN5O3 and a molecular weight of 485.938 g/mol. Key properties include a melting point of 100 - 102 °C, a boiling point of 676.9±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 363.2±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 850140-72-6
Jingsj CID: J-1957141-6
Molecular Formula: C₂₄H₂₅ClFN₅O₃
Molecular Weight: 485.938 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	100 - 102 °C
Boiling Point	676.9±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	363.2±31.5 °C
Exact Mass	485.162994
PSA	88.61000
LogP	3.59
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.668

Activity & Biological Data

Target	EGFR:0.5 nM (IC50) HER2:14 nM (IC50) EGFRL858R:0.4 nM (IC50) EGFRL858R/T790M:10 nM (IC50)
Additional Information	[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. [2]. Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99. [3]. Wang XK, et al. Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 2014 Dec 15;5(23):11971-85. [4]. Yoshioka T, et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr;109(4):1166-1176.

Target

EGFR:0.5 nM (IC50) HER2:14 nM (IC50) EGFRL858R:0.4 nM (IC50) EGFRL858R/T790M:10 nM (IC50)

Additional Information

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. [2]. Wong CH, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99. [3]. Wang XK, et al. Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo. Oncotarget. 2014 Dec 15;5(23):11971-85. [4]. Yoshioka T, et al. Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer. Cancer Sci. 2018 Apr;109(4):1166-1176.

Frequently Asked Questions

What is the CAS number of Afatinib?

The CAS number of Afatinib is 850140-72-6.

What are the molecular formula and molecular weight of Afatinib?

Afatinib has molecular formula C24H25ClFN5O3 and molecular weight 485.938 g/mol.

What are the upstream and downstream products of Afatinib?

For Afatinib, Upstream Products: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate, 2,2-Diethoxy-N,N-dimethylethanamine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Afatinib (CAS 850140-72-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1957141-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.