7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one

Also known as: Dehydro aripiprazole, Aripiprazole impurity E, Aripiprazole Related Compound G, Aripiprazole USP impurity G (EP impurity E), 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-2(1H)-quinolinone, 7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}quinolin-2(1H)-one, 2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-, DM 14857, OPC 14857

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (CAS 129722-25-4) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C23H25Cl2N3O2 and a molecular weight of 446.370 g/mol. Key properties include a boiling point of 654.4±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 349.6±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 129722-25-4
Jingsj CID: J-1956980-3
Molecular Formula: C₂₃H₂₅Cl₂N₃O₂
Molecular Weight: 446.370 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	654.4±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	349.6±31.5 °C
Exact Mass	445.132385
PSA	48.57000
LogP	5.64
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.605
Storage Conditions	?20°C

GHS Safety & Compliance

Flammable / Acute Toxicity / Health HazardSignal word: Danger

H225 — Highly flammable liquid and vapour
H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H370 — Causes damage to organs
H412 — Harmful to aquatic life with long lasting effects

Activity & Biological Data

Target	5-HT1A Receptor:4.2 nM (Ki)
Additional Information	[1]. Kirschbaum KM, et al. Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects. World J Biol Psychiatry. 2008;9(3):212-8. [2]. Lin SK, et al. Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia. J Clin Psychopharmacol. 2011 Dec;31(6):758-62. [3]. Hui-ChingHuang, et al. Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography–mass spectrometry in blood samples of psychiatric patients. Journal of Chromatography B. Volume 856, Issues 1-2, 1 September 2007, Pages 57-61. [4]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

Target

5-HT1A Receptor:4.2 nM (Ki)

Additional Information

[1]. Kirschbaum KM, et al. Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects. World J Biol Psychiatry. 2008;9(3):212-8. [2]. Lin SK, et al. Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia. J Clin Psychopharmacol. 2011 Dec;31(6):758-62. [3]. Hui-ChingHuang, et al. Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography–mass spectrometry in blood samples of psychiatric patients. Journal of Chromatography B. Volume 856, Issues 1-2, 1 September 2007, Pages 57-61. [4]. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one?

The CAS number of 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one is 129722-25-4.

What are the molecular formula and molecular weight of 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one?

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one has molecular formula C23H25Cl2N3O2 and molecular weight 446.370 g/mol.

Is 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one hazardous?

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.

What are the upstream and downstream products of 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one?

For 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one, Upstream Products: Aripiprazole, 1-(2,3-Dichlorophenyl)piperazine, 7-(4-Bromobutoxy)quinolin-2(1H)-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (CAS 129722-25-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956980-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.