Dibenzazepine

Also known as: YO-01027, DBZ, Dibenzazepine, Deshydroxy LY-411575, γ-Secretase Inhibitor XX, (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

Dibenzazepine (CAS 209984-56-5) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C26H23F2N3O3 and a molecular weight of 463.476 g/mol. Key properties include a melting point of 257-259ºC, a boiling point of 801.3±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 438.4±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 209984-56-5
Jingsj CID: J-1956967-3
Molecular Formula: C₂₆H₂₃F₂N₃O₃
Molecular Weight: 463.476 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	257-259ºC
Boiling Point	801.3±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	438.4±34.3 °C
Exact Mass	463.170746
PSA	78.51000
LogP	4.60
Appearance	white to beige
Vapor Pressure	0.0±2.8 mmHg at 25°C
Refractive Index	1.637
Storage Conditions	-20°C Freezer
Additional Property	DMSO: soluble15mg/mL, clear

Activity & Biological Data

Target	IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM[1]
Additional Information	[1]. Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. [2]. Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18. [3]. Zheng YH, et al. Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 2013 Dec 16;8(12):e83310. [4]. Xiao Z, et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71.

Target

IC50: 2.92±0.22 (Notch), 2.64±0.30 (APPL) nM[1]

Additional Information

[1]. Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74. [2]. Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18. [3]. Zheng YH, et al. Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 2013 Dec 16;8(12):e83310. [4]. Xiao Z, et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71.

Frequently Asked Questions

What is the CAS number of Dibenzazepine?

The CAS number of Dibenzazepine is 209984-56-5.

What are the molecular formula and molecular weight of Dibenzazepine?

Dibenzazepine has molecular formula C26H23F2N3O3 and molecular weight 463.476 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Dibenzazepine (CAS 209984-56-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956967-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.