2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole

Also known as: Rabeprazole thioether, Rabeprazole sulfide, Rabeprazole sulphide, H 295/43, 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)thio)-1H-benzimidazole, 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole, 2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole, MFCD08063845, Rabeprazole impurity F

2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole (CAS 117977-21-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C18H21N3O2S and a molecular weight of 343.443 g/mol. Key properties include a melting point of 120.5-121.5ºC, a boiling point of 546.4±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 284.2±32.9 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 117977-21-6
Jingsj CID: J-1956863-9
Molecular Formula: C₁₈H₂₁N₃O₂S
Molecular Weight: 343.443 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	120.5-121.5ºC
Boiling Point	546.4±60.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	284.2±32.9 °C
Exact Mass	343.135437
PSA	85.33000
LogP	3.53
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.636
Storage Conditions	-20°C Freezer

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73.

Additional Information

[1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole?

The CAS number of 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole is 117977-21-6.

What are the molecular formula and molecular weight of 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole?

2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole has molecular formula C18H21N3O2S and molecular weight 343.443 g/mol.

Is 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole hazardous?

2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole?

For 2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole, Upstream Products: 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine, 1H-Benzimidazole-2-thiol, 2-[(4-Chloro-3-methyl-2-pyridinyl)methyl]thio]-1H-benzimidazole; Downstream Products: Rabeprazole sodium, Rabeprazole, Rabeprazole EP Impurity A.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-{[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylthio}-1H-benzimidazole (CAS 117977-21-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956863-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.