![Molecular structure of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1254977-87-1)](/images/chem_structures_svg/499/1254977-87-1.svg)
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Also known as: JNJ-42153605, JNJ42153605, JNJ 42153605, CS-2446, 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine, 1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1254977-87-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C22H23F3N4 and a molecular weight of 400.44000 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1254977-87-1
- Jingsj CID
- J-1956574-3
- Molecular Formula
- C22H23F3N4
- Molecular Weight
- 400.44000 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Exact Mass | 400.18700 |
|---|---|
| PSA | 33.43000 |
| LogP | 5.14960 |
| Storage Conditions | 2-8℃ |
Activity & Biological Data
| Target | EC50: 17 nM (mGlu2 PAM)[1] |
|---|---|
| Additional Information | [1]. Cid JM, et al. Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor. J Med Chem. 2012 Oct 25;55(20):8770-89. |
Frequently Asked Questions
What is the CAS number of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine?
The CAS number of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine is 1254977-87-1.
What are the molecular formula and molecular weight of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine?
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine has molecular formula C22H23F3N4 and molecular weight 400.44000 g/mol.
What are the upstream and downstream products of 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine?
For 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine, Upstream Products: 4-Phenylpiperidine, 2,4-Dichloro-3-(trifluoromethyl)pyridine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1254977-87-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956574-3 (accessed 2026-11-09).
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