AZD1080
Also known as: AZD-1080, AZD 1080, 2-Hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 1H-Indole-5-carbonitrile, 2-hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-, 3-[5-(Morpholin-4-ylmethyl)-1H-pyridin-2-ylidene]-2-oxo-1H-indole-5-carbonitrile
AZD1080 (CAS 612487-72-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C19H18N4O2 and a molecular weight of 334.372 g/mol. Key properties include a boiling point of 594.0±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 313.0±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 612487-72-6
- Jingsj CID
- J-1956549-2
- Molecular Formula
- C19H18N4O2
- Molecular Weight
- 334.372 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 594.0±50.0 °C at 760 mmHg |
|---|---|
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 313.0±30.1 °C |
| Exact Mass | 334.142975 |
| PSA | 85.17000 |
| LogP | 1.36 |
| Vapor Pressure | 0.0±1.7 mmHg at 25°C |
| Refractive Index | 1.716 |
| Storage Conditions | -20°C |
Activity & Biological Data
| Target | GSK-3α:8.2 (pKi) GSK-3β:7.5 (pKi) cdk5:6.4 (pKi) cdk2:5.9 (pKi) cdk1:5.7 (pKi) |
|---|---|
| Additional Information | [1]. Georgievska B, et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013 May;125(3):446-56. |
Frequently Asked Questions
What is the CAS number of AZD1080?
The CAS number of AZD1080 is 612487-72-6.
What are the molecular formula and molecular weight of AZD1080?
AZD1080 has molecular formula C19H18N4O2 and molecular weight 334.372 g/mol.
What are the upstream and downstream products of AZD1080?
For AZD1080, Upstream Products: 5-bromo-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indol-2-ol, Zinc cyanide, 4-[(6-chloropyridin-3-yl)methyl]morpholine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "AZD1080 (CAS 612487-72-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956549-2 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.