Quiflapon

Also known as: MK-0591, MK 0591, MK 591, MK-591, L-686708, 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(2-quinolinylmethoxy)-1H-indole-2-propanoic acid, 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-, 3-[3-(tert-Butylsulfanyl)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropanoic acid, 3-[1-(4-Chlorobenzyl)-3-[(2-methyl-2-propanyl)sulfanyl]-5-(2-quinolinylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropanoic acid, Quiflapon [INN]

Quiflapon (CAS 136668-42-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C34H35ClN2O3S and a molecular weight of 587.171 g/mol. Key properties include a boiling point of 751.3±60.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 408.2±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 136668-42-3
Jingsj CID: J-1956298-2
Molecular Formula: C₃₄H₃₅ClN₂O₃S
Molecular Weight: 587.171 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	751.3±60.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	408.2±32.9 °C
Exact Mass	586.205688
PSA	89.65000
LogP	8.31
Vapor Pressure	0.0±2.6 mmHg at 25°C
Refractive Index	1.617
Storage Conditions	2-8℃

Activity & Biological Data

Target	IC50 value: 1.6 nM (FLAP)[1].
Additional Information	[1]. Brideau C, et al. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. [2]. Park MS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Lung. 2011 Feb;189(1):43-50.

Target

IC50 value: 1.6 nM (FLAP)[1].

Additional Information

[1]. Brideau C, et al. Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. [2]. Park MS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Lung. 2011 Feb;189(1):43-50.

Frequently Asked Questions

What is the CAS number of Quiflapon?

The CAS number of Quiflapon is 136668-42-3.

What are the molecular formula and molecular weight of Quiflapon?

Quiflapon has molecular formula C34H35ClN2O3S and molecular weight 587.171 g/mol.

What are the upstream and downstream products of Quiflapon?

For Quiflapon, Upstream Products: Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate, 2-(Bromomethyl)quinoline, Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-hydroxy-1H-indol-2-yl)-2,2-dimethylpropanoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Quiflapon (CAS 136668-42-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956298-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.