Trimetazidine

Also known as: 1-(2,3,4-Trimethoxybenzyl)piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine, Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, TMZ

Trimetazidine (CAS 5011-34-7) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H22N2O3 and a molecular weight of 266.34100 g/mol. Key properties include a melting point of 200 - 205ºC, a boiling point of 364.0±37.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 174.0±26.5 °C. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 5011-34-7
Jingsj CID: J-1956228-8
Molecular Formula: C₁₄H₂₂N₂O₃
Molecular Weight: 266.34100 g/mol
Category: Organic Compounds
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	200 - 205ºC
Boiling Point	364.0±37.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	174.0±26.5 °C
Exact Mass	274.213257
PSA	42.96000
LogP	0.80
Vapor Pressure	0.0±0.8 mmHg at 25°C
Refractive Index	1.524

Activity & Biological Data

Target	IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2] β-oxidation[2] Autophagy[3] 3-hydroxyacyl-CoA dehydrogenase (HADHA)[4]
Additional Information	[1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun;74(9):971-80. [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8. [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov;3(11):1236-47. [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun;19(5):300-2.

Target

IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2] β-oxidation[2] Autophagy[3] 3-hydroxyacyl-CoA dehydrogenase (HADHA)[4]

Additional Information

[1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun;74(9):971-80. [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8. [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov;3(11):1236-47. [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun;19(5):300-2.

Customs & Trade Information

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Trimetazidine?

The CAS number of Trimetazidine is 5011-34-7.

What are the molecular formula and molecular weight of Trimetazidine?

Trimetazidine has molecular formula C14H22N2O3 and molecular weight 266.34100 g/mol.

What are the upstream and downstream products of Trimetazidine?

For Trimetazidine, Upstream Products: ethyl 4-[(2,3,4-trimethoxyphenyl)methyl]piperazine-1-carboxylate, 2,3,4-Trimethoxybenzaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Trimetazidine (CAS 5011-34-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1956228-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.