Mefloquine hydrochloride

Also known as: Mefloquine HCl, Mefloquin hydrochloride, Loriam, WR142490, WR14249, Ro 21-5998/001, dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol, (R)-[2,8-Bis(trifluoromethyl)-4-quinolyl]-[(2S)-2-piperidyl]methanol hydrochloride, α-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, [2,8-Bis(trifluoromethyl)-4-quinolinyl](2-piperidinyl)methanol, 2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanol monohydrochloride

Mefloquine hydrochloride (CAS 51773-92-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C17H17ClF6N2O and a molecular weight of 414.77700 g/mol. Key properties include a melting point of 250-254ºC, a boiling point of 415.7±40.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 205.2±27.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.: 51773-92-3
Jingsj CID: J-1955874-8
Molecular Formula: C₁₇H₁₇ClF₆N₂O
Molecular Weight: 414.77700 g/mol
Category: Organic Acids
Last updated: 11/2/2026

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Physicochemical Properties

Melting Point	250-254ºC
Boiling Point	415.7±40.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	205.2±27.3 °C
Exact Mass	378.116669
PSA	45.15000
LogP	2.87
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.519
Storage Conditions	Refrigerator
Additional Property	DMSO: 38 mg/mL, soluble

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Additional Information	[1]. Kang J, Chen XL, Wang L, Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. [2]. Yan KH, Yao CJ, Hsiao CH, Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Boareto AC, Müller JC, Louren?o EL, Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos. Hum Exp Toxicol. 2013 Feb 19. [Epub ahead of print]

Additional Information

[1]. Kang J, Chen XL, Wang L, Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. [2]. Yan KH, Yao CJ, Hsiao CH, Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Boareto AC, Müller JC, Louren?o EL, Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos. Hum Exp Toxicol. 2013 Feb 19. [Epub ahead of print]

Frequently Asked Questions

What is the CAS number of Mefloquine hydrochloride?

The CAS number of Mefloquine hydrochloride is 51773-92-3.

What are the molecular formula and molecular weight of Mefloquine hydrochloride?

Mefloquine hydrochloride has molecular formula C17H17ClF6N2O and molecular weight 414.77700 g/mol.

Is Mefloquine hydrochloride hazardous?

Mefloquine hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Mefloquine hydrochloride?

For Mefloquine hydrochloride, Upstream Products: Methanone, [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinyl-, 2,8-Bis(trifluoromethyl)quinolin-4-ol, 2-(Chloromethyl)pyridine hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/2/2026

How to cite: Jingsj. "Mefloquine hydrochloride (CAS 51773-92-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955874-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.