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2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole

Also known as: 2-(2-Chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole, WAY-252623, LXR-623, LXR623, WAY 252623, 2H-Indazole, 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-

2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole (CAS 875787-07-8) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C21H12ClF5N2 and a molecular weight of 422.778 g/mol. Key properties include a melting point of 100 °C, a boiling point of 528.4±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 273.4±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
875787-07-8
Jingsj CID
J-1955649-1
Molecular Formula
C21H12ClF5N2
Molecular Weight
422.778 g/mol
Category
Aromatic Hydrocarbons
Last updated
8/21/2026
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Physicochemical Properties

Melting Point100 °C
Boiling Point528.4±50.0 °C at 760 mmHg
Density1.4±0.1 g/cm3
Flash Point273.4±30.1 °C
Exact Mass422.060913
PSA17.82000
LogP6.05
Vapor Pressure0.0±1.3 mmHg at 25°C
Refractive Index1.583

GHS Safety & Compliance

Acute ToxicitySignal word: Danger
  • H301 — Toxic if swallowed

Activity & Biological Data

TargetIC50: 24 nM (LXR-α), 179 nM (LXR-β)[2][3]
Additional Information[1]. Villa GR, et al. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14;30(5):683-693. [2]. Giannarelli C, et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis. Eur Heart J. 2012 Jan;33(2):264-73. [3]. Quinet EM, et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res. 2009 Dec;50(12):2358-70. [4]. DiBlasio-Smith EA, et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J Transl Med. 2008 Oct 16;6:59.

Frequently Asked Questions

What is the CAS number of 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole?

The CAS number of 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole is 875787-07-8.

What are the molecular formula and molecular weight of 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole?

2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole has molecular formula C21H12ClF5N2 and molecular weight 422.778 g/mol.

Is 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole hazardous?

2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole?

For 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole, Upstream Products: 2-Chloro-4-fluorobenzyl bromide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole (CAS 875787-07-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1955649-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.